Murine Pancreatic Adenocarcinoma Dampens SHIP-1 Expression and Alters MDSC Homeostasis and Function

BACKGROUND: Pancreatic cancer is one of the most aggressive cancers, with tumor-induced myeloid-derived suppressor cells (MDSC) contributing to its pathogenesis and ineffective therapies. In response to cytokine/chemokine receptor activation, src homology 2 domain-containing inositol 5′-phosphatase-...

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Detalhes bibliográficos
Main Authors: Pilon-Thomas, Shari, Nelson, Nadine, Vohra, Nasreen, Jerald, Maya, Pendleton, Laura, Szekeres, Karoly, Ghansah, Tomar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222660/
https://ncbi.nlm.nih.gov/pubmed/22132131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027729
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