Apigenin: Selective CK2 inhibitor increases Ikaros expression and improves T cell homeostasis and function in murine pancreatic cancer

Pancreatic cancer (PC) evades immune destruction by favoring the development of regulatory T cells (Tregs) that inhibit effector T cells. The transcription factor Ikaros is critical for lymphocyte development, especially T cells. We have previously shown that downregulation of Ikaros occurs as a res...

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Udgivet i:PLoS One
Main Authors: Nelson, Nadine, Szekeres, Karoly, Iclozan, Cristina, Rivera, Ivannie Ortiz, McGill, Andrew, Johnson, Gbemisola, Nwogu, Onyekachi, Ghansah, Tomar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289423/
https://ncbi.nlm.nih.gov/pubmed/28152014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170197
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