Functional factor XIII-A is exposed on the stimulated platelet surface

Factor XIII (FXIII) stabilizes thrombi against fibrinolysis by cross-linking α(2-)antiplasmin (α(2)AP) to fibrin. Cellular FXIII (FXIII-A) is abundant in platelets, but the extracellular functions of this pool are unclear because it is not released by classical secretion mechanisms. We examined the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Mitchell, Joanne L., Lionikiene, Ausra S., Fraser, Steven R., Whyte, Claire S., Booth, Nuala A., Mutch, Nicola J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309449/
https://ncbi.nlm.nih.gov/pubmed/25331118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-583070
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