Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity

Activated factor XII (FXIIa) has plasminogen activator capacity but its relative contribution to fibrinolysis is considered marginal compared with urokinase and tissue plasminogen activator. Polyphosphate (polyP) is released from activated platelets and mediates FXII activation. Here, we investigate...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Mitchell, Joanne L., Lionikiene, Ausra S., Georgiev, Georgi, Klemmer, Anja, Brain, Chelsea, Kim, Paul Y., Mutch, Nicola J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2016
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5325051/
https://ncbi.nlm.nih.gov/pubmed/27694320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-673285
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