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Neutral Substitutions Occur at a Faster Rate in Exons Than in Noncoding DNA in Primate Genomes

Point mutation rates in exons (synonymous sites) and noncoding (introns and intergenic) regions are generally assumed to be the same. However, comparative sequence analyses of synonymous substitutions in exons (81 genes) and that of long intergenic fragments (141.3 kbp) of human and chimpanzee genom...

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Detalhes bibliográficos
Main Authors: Subramanian, Sankar, Kumar, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC430942/
https://ncbi.nlm.nih.gov/pubmed/12727904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1152803
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