Tuning phenols with Intra-Molecular bond Shifted HYdrogens as diaCEST MRI contrast agents

We characterize what the optimal exchange properties are for CEST contrast agents on 3T clinical scanners using CW saturation transfer, and demonstrate that the exchangeable protons in phenols can be tuned to reach these criteria through proper ring substitution. Systematic modification allows the c...

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Dettagli Bibliografici
Pubblicato in:Chemistry
Autori principali: Yang, Xing, Yadav, Nirbhay N., Song, Xiaolei, Banerjee, Sangeeta Ray, Edelman, Hannah, Minn, Il, van Zijl, Peter C. M., Pomper, Martin G., McMahon, Michael T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309366/
https://ncbi.nlm.nih.gov/pubmed/25302635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201403943
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