Tuning phenols with Intra-Molecular bond Shifted HYdrogens as diaCEST MRI contrast agents

We characterize what the optimal exchange properties are for CEST contrast agents on 3T clinical scanners using CW saturation transfer, and demonstrate that the exchangeable protons in phenols can be tuned to reach these criteria through proper ring substitution. Systematic modification allows the c...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Yang, Xing, Yadav, Nirbhay N., Song, Xiaolei, Banerjee, Sangeeta Ray, Edelman, Hannah, Minn, Il, van Zijl, Peter C. M., Pomper, Martin G., McMahon, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309366/
https://ncbi.nlm.nih.gov/pubmed/25302635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201403943
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