Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

BACKGROUND: The molecular mechanisms underlying autistic behaviors remain to be elucidated. Mutations in genes linked to autism adversely affect molecules regulating dendritic spine formation, function and plasticity, and some increase the mammalian target of rapamycin, mTOR, a regulator of protein...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Nicolini, Chiara, Ahn, Younghee, Michalski, Bernadeta, Rho, Jong M, Fahnestock, Margaret
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307681/
https://ncbi.nlm.nih.gov/pubmed/25627160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0184-4
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