Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells

Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; however its therapeutic effects in leukemia treatment...

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Publicado no:Int J Mol Sci
Main Authors: Wang, Na-Na, Li, Zhi-Heng, Zhao, He, Tao, Yan-Fang, Xu, Li-Xiao, Lu, Jun, Cao, Lan, Du, Xiao-Juan, Sun, Li-Chao, Zhao, Wen-Li, Xiao, Pei-Fang, Fang, Fang, Su, Guang-Hao, Li, Yan-Hong, Li, Gang, Li, Yi-Ping, Xu, Yun-Yun, Zhou, Hui-Ting, Wu, Yi, Jin, Mei-Fang, Liu, Lin, Ni, Jian, Wang, Jian, Hu, Shao-Yan, Zhu, Xue-Ming, Feng, Xing, Pan, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307303/
https://ncbi.nlm.nih.gov/pubmed/25574601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms16011266
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