A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors

Injectable, degradation-resistant peptide agonists for the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R), such as exenatide and liraglutide, activate the GLP-1R via a complex orthosteric-binding site and are effective therapeutics for glycemic control in type 2 diabetes. Orally bioavailable orth...

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Detalhes bibliográficos
Publicado no:J Biomol Screen
Main Authors: Morris, Lindsey C., Days, Emily L., Turney, Maxine, Mi, Dehui, Lindsley, Craig W., Weaver, C. David, Niswender, Kevin D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306651/
https://ncbi.nlm.nih.gov/pubmed/24525870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114520971
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