Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

KCC2, a neuronal-specific K-Cl cotransporter, plays a major role in maintaining intracellular Cl(−) concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses. The pharmacology of the K-Cl cotransporter is dominated by...

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Main Authors: Delpire, Eric, Days, Emily, Lewis, L. Michelle, Mi, Dehui, Kim, Kwangho, Lindsley, Craig W., Weaver, C. David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654392/
https://ncbi.nlm.nih.gov/pubmed/19279215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812756106
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