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Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2
KCC2, a neuronal-specific K-Cl cotransporter, plays a major role in maintaining intracellular Cl(−) concentration in neurons below its electrochemical equilibrium potential, thus favoring robust GABA hyperpolarizing or inhibitory responses. The pharmacology of the K-Cl cotransporter is dominated by...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654392/ https://ncbi.nlm.nih.gov/pubmed/19279215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812756106 |
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