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Challenges of finding novel drugs targeting the K-Cl cotransporter
Human-disease causing mutations and genetically-modified mouse models have established the importance of KCC2 and KCC3 in nervous system physiology. These two proteins mediate the electroneutral cotransport of K(+) and Cl(−) ions across the neuronal membrane. Disruption of KCC2 function affects inhi...
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| Publicado no: | ACS Chem Neurosci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473358/ https://ncbi.nlm.nih.gov/pubmed/27998063 |
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