Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2

GABA-mediated fast-hyperpolarizing inhibition depends on extrusion of chloride by the neuron-specific K-Cl cotransporter, KCC2. Here we show that sustained interictal-like activity in hippocampal slices downregulates KCC2 mRNA and protein expression in CA1 pyramidal neurons, which leads to a reduced...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Rivera, Claudio, Voipio, Juha, Thomas-Crusells, Judith, Li, Hong, Emri, Zsuzsa, Sipilä, Sampsa, Payne, John A., Minichiello, Liliana, Saarma, Mart, Kaila, Kai
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2004
Sujets:
Cellular/Molecular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729393/
https://ncbi.nlm.nih.gov/pubmed/15140939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5265-03.2004
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