BDNF-induced TrkB activation down-regulates the K(+)–Cl(−) cotransporter KCC2 and impairs neuronal Cl(−) extrusion

Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl(−) regulation, which can lead to a suppression of fast postsynaptic GABAergic responses. Brain-derived neurotrophic factor (BDNF) increases neuronal excitability through...

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Bibliographic Details
Main Authors: Rivera, Claudio, Li, Hong, Thomas-Crusells, Judith, Lahtinen, Hannele, Viitanen, Tero, Nanobashvili, Avtandil, Kokaia, Zaal, Airaksinen, Matti S., Voipio, Juha, Kaila, Kai, Saarma, Mart
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173387/
https://ncbi.nlm.nih.gov/pubmed/12473684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209011
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