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BDNF-induced TrkB activation down-regulates the K(+)–Cl(−) cotransporter KCC2 and impairs neuronal Cl(−) extrusion
Pathophysiological activity and various kinds of traumatic insults are known to have deleterious long-term effects on neuronal Cl(−) regulation, which can lead to a suppression of fast postsynaptic GABAergic responses. Brain-derived neurotrophic factor (BDNF) increases neuronal excitability through...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173387/ https://ncbi.nlm.nih.gov/pubmed/12473684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200209011 |
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