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Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
The melanocortin MC(4) receptor is a potential target for the development of drugs for both obesity and cachexia. Melanocortin MC(4) receptor ligands known thus far are orthosteric agonists or antagonists, however the agonists, in particular, have generally exhibited unwanted side effects. For some...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3175485/ https://ncbi.nlm.nih.gov/pubmed/21296065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2011.01.031 |
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