Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu(4) positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS)

[Image: see text] Herein we disclose the synthesis and SAR of a series of 4-(phenylsulfamoyl)phenylacetamide compounds as mGlu(4) positive allosteric modulators (PAMs) that were identified via a functional HTS. An iterative parallel approach to these compounds culminated in the discovery of VU036443...

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Detalhes bibliográficos
Main Authors: Engers, Darren W., Gentry, Patrick R., Williams, Richard, Bolinger, Julie L., Weaver, C. David, Menon, Usha N., Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922490/
https://ncbi.nlm.nih.gov/pubmed/20667732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.07.007
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