Efficacy and Toxicity of Peritumoral Delivery of Nanoconjugated Cisplatin in an In Vivo Murine Model of Head and Neck Squamous Cell Carcinoma

IMPORTANCE: Treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) uses a multi-disciplinary approach often limited by the toxicity and drug resistance of platinum agents. OBJECTIVES: To test whether a nanocarrier-conjugated cisplatin boosting locoregional drug delivery improves...

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Опубликовано в: :JAMA Otolaryngol Head Neck Surg
Главные авторы: Cohen, Stephanie M., Rockefeller, Nick, Mukerji, Ridhwi, Durham, Dianne, Forrest, M. Laird, Cai, Shuang, Cohen, Mark S., Shnayder, Yelizaveta
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306558/
https://ncbi.nlm.nih.gov/pubmed/23599074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoto.2013.214
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