Subcutaneous Delivery of Nanoconjugated Doxorubicin and Cisplatin for Locally Advanced Breast Cancer Demonstrates Improved Efficacy and Decreased Toxicity at Lower Doses Than Standard Systemic Combination Therapy In Vivo

BACKGROUND: Combination cytotoxic agents in breast cancer carry dose-limiting toxicities. We hypothesize that nanocarrier-conjugated doxorubicin and cisplatin will have improved tumor efficacy with decreased systemic toxicity over standard drugs, even at lower doses. METHODS: Female Nu/Nu mice were...

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Bibliografiska uppgifter
I publikationen:Am J Surg
Huvudupphovsmän: Cohen, Stephanie M., Mukerji, Ridhwi, Cai, Shuang, Damjanov, Ivan, Forrest, M. Laird, Cohen, Mark S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198781/
https://ncbi.nlm.nih.gov/pubmed/21982998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2011.06.027
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