New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics

[Image: see text] Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W...

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Pubblicato in:J Med Chem
Autori principali: Gorham, Ronald D., Forest, David L., Khoury, George A., Smadbeck, James, Beecher, Consuelo N., Healy, Evangeline D., Tamamis, Phanourios, Archontis, Georgios, Larive, Cynthia K., Floudas, Christodoulos A., Radeke, Monte J., Johnson, Lincoln V., Morikis, Dimitrios
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306506/
https://ncbi.nlm.nih.gov/pubmed/25494040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501345y
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