Novel Compstatin Family Peptides Inhibit Complement Activation by Drusen-Like Deposits in Human Retinal Pigmented Epithelial Cell Cultures

We have used a novel human retinal pigmented epithelial (RPE) cell-based model that mimics drusen biogenesis and the pathobiology of age-related macular degeneration to evaluate the efficacy of newly designed peptide inhibitors of the complement system. The peptides belong to the compstatin family a...

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Detalhes bibliográficos
Main Authors: Gorham, Ronald D., Forest, David L., Tamamis, Phanourios, de Victoria, Aliana López, Kraszni, Márta, Kieslich, Chris A., Banna, Christopher D., Bellows-Peterson, Meghan L., Larive, Cynthia K., Floudas, Christodoulos A., Archontis, Georgios, Johnson, Lincoln V., Morikis, Dimitrios
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840162/
https://ncbi.nlm.nih.gov/pubmed/23954241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2013.07.023
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