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Design of a Modified Mouse Protein with Ligand Binding Properties of its Human Analog by Molecular Dynamics Simulations: The Case of C3 Inhibition by Compstatin
The peptide compstatin and its derivatives inhibit the complement-component protein C3 in primate mammals and are potential therapeutic agents against unregulated activation of complement in humans, but are inactive against C3 from lower mammals. Recent molecular dynamics (MD) simulations showed tha...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3193182/ https://ncbi.nlm.nih.gov/pubmed/21989937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23149 |
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