New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics

[Image: see text] Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Gorham, Ronald D., Forest, David L., Khoury, George A., Smadbeck, James, Beecher, Consuelo N., Healy, Evangeline D., Tamamis, Phanourios, Archontis, Georgios, Larive, Cynthia K., Floudas, Christodoulos A., Radeke, Monte J., Johnson, Lincoln V., Morikis, Dimitrios
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306506/
https://ncbi.nlm.nih.gov/pubmed/25494040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501345y
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