New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics

[Image: see text] Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Gorham, Ronald D., Forest, David L., Khoury, George A., Smadbeck, James, Beecher, Consuelo N., Healy, Evangeline D., Tamamis, Phanourios, Archontis, Georgios, Larive, Cynthia K., Floudas, Christodoulos A., Radeke, Monte J., Johnson, Lincoln V., Morikis, Dimitrios
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306506/
https://ncbi.nlm.nih.gov/pubmed/25494040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501345y
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