A Human Type 5 Adenovirus-Based Trypanosoma cruzi Therapeutic Vaccine Re-programs Immune Response and Reverses Chronic Cardiomyopathy

Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a prototypical neglected tropical disease. Specific immunity promotes acute phase survival. Nevertheless, one-third of CD patients develop chronic chagasic cardiomyopathy (CCC) associated with parasite persistence and immunological u...

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發表在:PLoS Pathog
Main Authors: Pereira, Isabela Resende, Vilar-Pereira, Glaucia, Marques, Virgínia, da Silva, Andrea Alice, Caetano, Bráulia, Moreira, Otacilio Cruz, Machado, Alexandre Vieira, Bruna-Romero, Oscar, Rodrigues, Maurício Martins, Gazzinelli, Ricardo Tostes, Lannes-Vieira, Joseli
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305326/
https://ncbi.nlm.nih.gov/pubmed/25617628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004594
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