Binge alcohol promotes hypoxicliver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans

Binge drinking, a common pattern of alcohol ingestion, is known to potentiate liver injury caused by chronic alcohol abuse. This study was aimed to investigate theeffects of acute binge alcohol onhypoxia-inducible factor-1α (HIF-1α)-mediated liver injury and rolesof alcohol metabolizing enzymes in a...

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Gepubliceerd in:Free Radic Biol Med
Hoofdauteurs: Yun, Jun-Won, Son, Min-Jeong, Abdelmegeed, Mohamed A., Banerjee, Atrayee, Morgan, Timothy R., Yoo, Seong-Ho, Song, Byoung-Joon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304203/
https://ncbi.nlm.nih.gov/pubmed/25236742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.030
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