Excess SMAD signaling contributes to heart and muscle dysfunction in muscular dystrophy

Disruption of the dystrophin complex causes muscle injury, dysfunction, cell death and fibrosis. Excess transforming growth factor (TGF) β signaling has been described in human muscular dystrophy and animal models, where it is thought to relate to the progressive fibrosis that characterizes dystroph...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Goldstein, Jeffery A., Bogdanovich, Sasha, Beiriger, Anastasia, Wren, Lisa M., Rossi, Ann E., Gao, Quan Q., Gardner, Brandon B., Earley, Judy U., Molkentin, Jeffery D., McNally, Elizabeth M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303797/
https://ncbi.nlm.nih.gov/pubmed/25070948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu390
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