SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy

Loss-of-function mutations in the genes encoding dystrophin and the associated membrane proteins, the sarcoglycans, produce muscular dystrophy and cardiomyopathy. The dystrophin complex provides stability to the plasma membrane of striated muscle during muscle contraction. Increased SMAD signaling d...

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Main Authors: Goldstein, Jeffery A., Kelly, Sean M., LoPresti, Peter P., Heydemann, Ahlke, Earley, Judy U., Ferguson, Edwin L., Wolf, Matthew J., McNally, Elizabeth M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033181/
https://ncbi.nlm.nih.gov/pubmed/21138941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq528
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