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Epigenetic Modification of Histone 3 Lysine 27: MEDIATOR SUBUNIT MED25 IS REQUIRED FOR THE DISSOCIATION OF POLYCOMB REPRESSIVE COMPLEX 2 FROM THE PROMOTER OF CYTOCHROME P450 2C9

The Mediator complex is vital for the transcriptional regulation of eukaryotic genes. Mediator binds to nuclear receptors at target response elements and recruits chromatin-modifying enzymes and RNA polymerase II. Here, we examine the involvement of Mediator subunit MED25 in the epigenetic regulatio...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Englert, Neal A., Luo, George, Goldstein, Joyce A., Surapureddi, Sailesh
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303677/
https://ncbi.nlm.nih.gov/pubmed/25391650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.579474
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