THE COACTIVATOR NCOA6 MEDIATES THE SYNERGISTIC ACTIVATION OF HUMAN CYTOCHROME P-450 2C9 BY THE CONSTITUTIVE ANDROSTANE RECEPTOR AND HEPATIC NUCLEAR FACTOR-4α

Nuclear receptor coactivator 6 (NCOA6) also known as PRIP/RAP250/ASC-2 anchors a steady state complex of cofactors and function as a transcriptional coactivator for certain nuclear receptors. This is the first study to identify NCOA6 as an HNF4α interacting protein. CYP2C9 is an important enzyme whi...

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Autores principales: Surapureddi, Sailesh, Rana, Ritu, Reddy, Janardan K, Goldstein, Joyce A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815599/
https://ncbi.nlm.nih.gov/pubmed/18552123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.048983
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