Differential Ubiquitin Binding by the Acidic Loops of Ube2g1 and Ube2r1 Enzymes Distinguishes Their Lys-48-ubiquitylation Activities

The ubiquitin E2 enzymes, Ube2g1 and Ube2r1, are able to synthesize Lys-48-linked polyubiquitins without an E3 ligase but how that is accomplished has been unclear. Although both E2s contain essential acidic loops, only Ube2r1 requires an additional C-terminal extension (184–196) for efficient Lys-4...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Choi, Yun-Seok, Lee, Yun-Ju, Lee, Seo-Yeon, Shi, Lei, Ha, Jung-Hye, Cheong, Hae-Kap, Cheong, Chaejoon, Cohen, Robert E., Ryu, Kyoung-Seok
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303676/
https://ncbi.nlm.nih.gov/pubmed/25471371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624809
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