Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

Pairing of a given E3 ubiquitin ligase with different E2s allows synthesis of ubiquitin conjugates of different topologies. While this phenomenon contributes to functional diversity, it remains largely unknown how a single E3 ubiquitin ligase recognizes multiple E2s, and whether identical structural...

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Bibliografiske detaljer
Main Authors: Lok, Gabriel Tsz-Mei, Sy, Shirley M.-H., Dong, Sui-Sui, Ching, Yick-Pang, Tsao, Sai Wah, Thomson, Timothy M., Huen, Michael S. Y.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245915/
https://ncbi.nlm.nih.gov/pubmed/21911360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr655
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