Cyclic GMP Kinase II (cGKII) Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites: IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE

The epithelial brush-border Na(+)/H(+) exchanger NHE3 is acutely inhibited by cGKII/cGMP, but how cGKII inhibits NHE3 is unknown. This study tested the hypothesis that cGMP inhibits NHE3 by phosphorylating it and altering its membrane trafficking. Studies were carried out in PS120/NHERF2 and in Caco...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chen, Tiane, Kocinsky, Hetal S., Cha, Boyoung, Murtazina, Rakhilya, Yang, Jianbo, Tse, C. Ming, Singh, Varsha, Cole, Robert, Aronson, Peter S., de Jonge, Hugo, Sarker, Rafiquel, Donowitz, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303652/
https://ncbi.nlm.nih.gov/pubmed/25480791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.590174
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