Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency

Δ-6-fatty acid desaturase (FADS2) is the key enzyme in the biosynthesis of polyunsaturated fatty acids (PUFAs), the essential structural determinants of mammalian membrane lipid-bilayers. We developed the auxotrophic fads2(−/−) mouse mutant to assess the enigmatic role of ω3- and ω6-PUFAs in lipid h...

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Publicat a:EMBO Rep
Autors principals: Stoffel, Wilhelm, Hammels, Ina, Jenke, Britta, Binczek, Erika, Schmidt-Soltau, Inga, Brodesser, Susanne, Odenthal, Margarete, Thevis, Mario
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303455/
https://ncbi.nlm.nih.gov/pubmed/24378641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201338041
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