Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

[Image: see text] Despite two decades of research, the structure–function relationships of endogenous, physiological forms of α-synuclein (αSyn) are not well understood. Most in vitro studies of this Parkinson’s disease-related protein have focused on recombinant αSyn that is unfolded and monomeric,...

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Vydáno v:Biochemistry
Hlavní autoři: Luth, Eric S., Bartels, Tim, Dettmer, Ulf, Kim, Nora C., Selkoe, Dennis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303315/
https://ncbi.nlm.nih.gov/pubmed/25490121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501188a
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