Tamoxifen induces apoptosis through cancerous inhibitor of protein phosphatase 2A–dependent phospho-Akt inactivation in estrogen receptor–negative human breast cancer cells

INTRODUCTION: Tamoxifen, a selective estrogen receptor (ER) modulator, may affect cancer cell survival through mechanisms other than ER antagonism. In the present study, we tested the efficacy of tamoxifen in a panel of ER-negative breast cancer cell lines and examined the drug mechanism. METHODS: I...

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Vydáno v:Breast Cancer Res
Hlavní autoři: Liu, Chun-Yu, Hung, Man-Hsin, Wang, Duen-Shian, Chu, Pei-Yi, Su, Jung-Chen, Teng, Tsung-Han, Huang, Chun-Teng, Chao, Ting-Ting, Wang, Cheng-Yi, Shiau, Chung-Wai, Tseng, Ling-Ming, Chen, Kuen-Feng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303112/
https://ncbi.nlm.nih.gov/pubmed/25228280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0431-9
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