Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome

Previously, we reported that cancerous inhibitor of protein phosphatase 2A (CIP2A) mediates the apoptotic effect of bortezomib in hepatocellular carcinoma (HCC). Here, we report a proteasome-independent mechanism by which bortezomib induces autophagy in HCC. Our data indicate that bortezomib activat...

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Detalhes bibliográficos
Main Authors: Yu, Hui-Chuan, Hou, Duen-Ren, Liu, Chun-Yu, Lin, Chen-Si, Shiau, Chung-Wai, Cheng, Ann-Lii, Chen, Kuen-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562236/
https://ncbi.nlm.nih.gov/pubmed/23383345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055705
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