Global mRNA selection mechanisms for translation initiation

BACKGROUND: The selection and regulation of individual mRNAs for translation initiation from a competing pool of mRNA are poorly understood processes. The closed loop complex, comprising eIF4E, eIF4G and PABP, and its regulation by 4E-BPs are perceived to be key players. Using RIP-seq, we aimed to e...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Costello, Joseph, Castelli, Lydia M, Rowe, William, Kershaw, Christopher J, Talavera, David, Mohammad-Qureshi, Sarah S, Sims, Paul F G, Grant, Christopher M, Pavitt, Graham D, Hubbard, Simon J, Ashe, Mark P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302535/
https://ncbi.nlm.nih.gov/pubmed/25650959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0559-z
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