The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

Translation initiation factor eIF4E mediates mRNA selection for protein synthesis via the mRNA 5’cap. A family of binding proteins, termed the 4E-BPs, interact with eIF4E to hinder ribosome recruitment. Mechanisms underlying mRNA specificity for 4E-BP control remain poorly understood. Saccharomyces...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Castelli, Lydia M., Talavera, David, Kershaw, Christopher J., Mohammad-Qureshi, Sarah S., Costello, Joseph L., Rowe, William, Sims, Paul F. G., Grant, Christopher M., Hubbard, Simon J., Ashe, Mark P., Pavitt, Graham D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431810/
https://ncbi.nlm.nih.gov/pubmed/25973932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005233
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