Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations

Cardiac troponin (cTn) is a key molecule in the regulation of human cardiac muscle contraction. The N-terminal cardiac-specific peptide of the inhibitory subunit of troponin, cTnI (cTnI(1-39)), is a target for phosphorylation by protein kinase A (PKA) during β-adrenergic stimulation. We recently pre...

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Vydáno v:Biophys J
Hlavní autoři: Lindert, Steffen, Cheng, Yuanhua, Kekenes-Huskey, Peter, Regnier, Michael, McCammon, J. Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2015
Témata:
Proteins and Nucleic Acids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302190/
https://ncbi.nlm.nih.gov/pubmed/25606687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.11.3461
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