The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer

PURPOSE: Activation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mTOR pathway has been implicated in anti-estrogen resistance in breast cancer. We tested the therapeutic potential of the novel PI3K/mTOR dual inhibitor P7170 in a panel of anti-estrogen-sensitive and -resistant models of ER+ breast...

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Udgivet i:Breast Cancer Res Treat
Main Authors: Bean, Jennifer R., Hosford, Sarah R., Symonds, Lynn K., Owens, Philip, Dillon, Lloye M., Yang, Wei, Shee, Kevin, Schwartz, Gary N., Marotti, Jonathan D., Muller, Kristen E., Rosenkranz, Kari M., Barth, Richard J., Chen, Vivian S., Agarwal, Veena R., Miller, Todd W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302040/
https://ncbi.nlm.nih.gov/pubmed/25491778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-014-3201-6
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