Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart

BACKGROUND: Changes in energy substrate metabolism are first responders to hemodynamic stress in the heart. We have previously shown that hexose‐6‐phosphate levels regulate mammalian target of rapamycin (mTOR) activation in response to insulin. We now tested the hypothesis that inotropic stimulation...

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Detalhes bibliográficos
Main Authors: Sen, Shiraj, Kundu, Bijoy K., Wu, Henry Cheng‐Ju, Hashmi, S. Shahrukh, Guthrie, Patrick, Locke, Landon W., Roy, R. Jack, Matherne, G. Paul, Berr, Stuart S., Terwelp, Matthew, Scott, Brian, Carranza, Sylvia, Frazier, O. Howard, Glover, David K., Dillmann, Wolfgang H., Gambello, Michael J., Entman, Mark L., Taegtmeyer, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698799/
https://ncbi.nlm.nih.gov/pubmed/23686371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.004796
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