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Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart

OBJECTIVE: Insulin regulates both glucose uptake and postnatal cardiac growth. The anabolic effects of insulin are mediated by the mammalian target of rapamycin (mTOR), an evolutionarily conserved kinase which is also a convergence point between nutrient sensing and cell growth. We postulated that m...

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Detalhes bibliográficos
Main Authors: Sharma, Saumya, Guthrie, Patrick, Chan, Suzanne, Haq, Syed, Taegtmeyer, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2257479/
https://ncbi.nlm.nih.gov/pubmed/17553476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cardiores.2007.05.004
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