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Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing
BACKGROUND: Cell migration requires coordinated formation of focal adhesions (FAs) and assembly and contraction of the actin cytoskeleton. Non-muscle myosin II (MII) is a critical mediator of contractility and FA dynamics in cell migration. Signaling downstream of the small GTPase Rac1 also regulate...
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| Veröffentlicht in: | Curr Biol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4302036/ https://ncbi.nlm.nih.gov/pubmed/25544611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.11.043 |
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