Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensing

BACKGROUND: Cell migration requires coordinated formation of focal adhesions (FAs) and assembly and contraction of the actin cytoskeleton. Non-muscle myosin II (MII) is a critical mediator of contractility and FA dynamics in cell migration. Signaling downstream of the small GTPase Rac1 also regulate...

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Udgivet i:Curr Biol
Main Authors: Pasapera, Ana M., Plotnikov, Sergey V., Fischer, Robert S., Case, Lindsay B., Egelhoff, Thomas T., Waterman, Clare M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302036/
https://ncbi.nlm.nih.gov/pubmed/25544611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.11.043
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