Myosin IIA Heavy Chain Phosphorylation Mediates Adhesion Maturation and Protrusion in Three Dimensions

Non-muscle myosin II (NMII) is a conserved force-producing cytoskeletal enzyme with important but poorly understood roles in cell migration. To investigate myosin heavy chain (MHC) phosphorylation roles in 3D migration, we expressed GFP-tagged NMIIA wild-type or mutant constructs in cells depleted o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Rai, Vandana, Thomas, Dustin G., Beach, Jordan R., Egelhoff, Thomas T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336147/
https://ncbi.nlm.nih.gov/pubmed/28053086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733402
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