Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons

In primary cultures of mesencephalon small-conductance calcium-activated potassium channels (SK) are expressed in dopaminergic neurons. We characterized SK-mediated currents (I(SK)) in this system and evaluated their role on homeostasis against excitotoxicity. I(SK) amplitude was reduced by the glut...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Benítez, Bruno A., Belálcazar, Helen M., Anastasía, Agustín, Mamah, Daniel T., Zorumski, Charles F., Mascó, Daniel H., Herrera, Daniel G., de Erausquin, Gabriel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301957/
https://ncbi.nlm.nih.gov/pubmed/21044638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.10.024
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