Age-dependent neuroprotective effect of an SK3 channel agonist on excitotoxity to dopaminergic neurons in organotypic culture

BACKGROUND: Small conductance, calcium-activated (SK3) potassium channels control the intrinsic excitability of dopaminergic neurons (DN) in the midbrain and modulate their susceptibility to toxic insults during development. METHODS: We evaluated the age-dependency of the neuroprotective effect of a...

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Pubblicato in:PLoS One
Autori principali: Maldonado, Oscar, Jenkins, Alexandra, Belalcazar, Helen M., Hernandez-Cuervo, Helena, Hyman, Katelynn M., Ladaga, Giannina, Padilla, Lucia, de Erausquin, Gabriel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377472/
https://ncbi.nlm.nih.gov/pubmed/32701951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223633
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