Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands()

Earlier, we found estrogen receptor (ER) ligands having a novel three-dimensional oxabicyclo[2.2.1]heptene core scaffold and good ER binding affinity acted as partial agonists via small alkyl ester substitutions on the bicyclic core that indirectly modulate the critical switch helix in the ER ligand...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Zheng, Yangfan, Zhu, Manghong, Srinivasan, Sathish, Nwachukwu, Jerome C., Cavett, Valerie, Min, Jian, Carlson, Kathryn E., Wang, Pengcheng, Dong, Chune, Katzenellenbogen, John A., Nettles, Kendall W., Zhou, Hai-Bing
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301955/
https://ncbi.nlm.nih.gov/pubmed/22517684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200048
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados