Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells

BACKGROUND: Human Langerhans cells (LCs) reside in foreskin and vaginal mucosa and are the first immune cells to interact with HIV-1 during sexual transmission. LCs capture HIV-1 through the C-type lectin receptor langerin, which routes the virus into Birbeck granules (BGs), thereby preventing HIV-1...

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Bibliographic Details
Published in:Retrovirology
Main Authors: van den Berg, Linda M, Ribeiro, Carla M S, Zijlstra-Willems, Esther M, de Witte, Lot, Fluitsma, Donna, Tigchelaar, Wikky, Everts, Vincent, Geijtenbeek, Teunis B H
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301922/
https://ncbi.nlm.nih.gov/pubmed/25551286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0123-7
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