Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission

BACKGROUND: Sexual transmission is the main route of HIV-1 infection and the CCR5-using (R5) HIV-1 is predominantly transmitted, even though CXCR4-using (X4) HIV-1 is often abundant in chronic HIV-1 patients. The mechanisms underlying this tropism selection are unclear. Mucosal Langerhans cells (LCs...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Sarrami-Forooshani, Ramin, Mesman, Annelies W, van Teijlingen, Nienke H, Sprokholt, Joris K, van der Vlist, Michiel, Ribeiro, Carla MS, Geijtenbeek, Teunis BH
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227116/
https://ncbi.nlm.nih.gov/pubmed/24990163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-52
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