TNF-α and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo

Genital coinfections increase an individual’s risk of becoming infected with HIV-1 by sexual contact. Several mechanisms have been proposed to explain this, such as the presence of ulceration and bleeding caused by the coinfecting pathogen. Here we demonstrate that Langerhans cells (LCs) are involve...

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Autori principali: de Jong, Marein A.W.P., de Witte, Lot, Oudhoff, Menno J., Gringhuis, Sonja I., Gallay, Philippe, Geijtenbeek, Teunis B.H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528910/
https://ncbi.nlm.nih.gov/pubmed/18776939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34721
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